Spy vs. Spy is a wordless black and white comic strip that has been published in Mad magazine since 1961. It was created by Cuban cartoonist Antonio Prohías, who fled to the United States in 1960 (just days before Fidel Castro took over the Cuban free press).

The "Spy vs. Spy" cartoon was symbolic of the Cold War, and was Prohías's comment on the futility of armed escalation and détente. Under the Spy vs. Spy title panel, the words "BY PROHIAS" are spelled out in Morse code, which would be: -••• -•-- •--• •-• --- •••• •• •- •••.

In 1987, Prohías retired from writing "Spy vs. Spy", and following his retirement, the strip was written and drawn by the late Don "Duck" Edwing (1934-2016) and Bob Clarke (1926-2013), respectively. In 1997, one year before Prohías' death, American cartoonist Peter Kuper took over as writer and artist, who continues to pen strips for Mad to this day.

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